NAD+ is a coenzyme that is involved in a broad number of biological functions. Starting around the age of 30, naturally occurring levels of NAD+ begin to decline, and continue to diminish as time passes. Because it is present in every living cell and aids in so many vital processes—regulating circadian rhythm, DNA repair functions, and immune system health—the decline in NAD+ levels can be linked to a number of health problems. These problems can include various cancers, neurodegenerative diseases like Alzheimer’s and Parkinson’s, and metabolic disorders.
BENEFITS OF SUPPLEMENTATION WITH NAD+
- Promotes healthy aging and extends lifespan
- Boosts energy
- Improves overall health
- Increases metabolism and supports weight loss
- Protects brain cells from oxidative stress and insufficient blood flow
- Promotes proper functioning of mitochondrial cells
- Reduces atherosclerosis (plaque buildup in arterial walls)
- Supports better cardiovascular health by restoring arterial elasticity
- Maintains and/or improves cognitive function
- Improves muscle function
- Enhances skeletal muscle development and mitochondrial health
- Supports immune system activity (which consumes NAD+ as it becomes more active)
- Linked to sirtuins, proteins essential to healthy aging, metabolism regulation, DNA repair, and chromosomal stability
POSSIBLE SIDE EFFECTS
- Diarrhea
- Bruising easily
- Increased wound bleeding
- Nausea
- Vomiting
EXCESSIVE INTAKE (OVER 3,000 MG/MONTH) MAY LEAD TO:
- Liver damage
- Kidney disease
- Increased risk of vascular complications
CONTRAINDICATIONS
Do NOT take NAD+ if:
- You are pregnant or breastfeeding
- You are diabetic — use with caution due to potential insulin resistance, high blood sugar, and glucose intolerance
- You have active cancer or are undergoing cancer treatment
- You are taking blood pressure medications — NAD+ may enhance their effects and lead to hypotension
- You are on anticoagulants such as Coumadin/Warfarin — NAD+ may interfere with blood clotting
- You are taking antidepressants — NAD+ may worsen mood-related symptoms
- You are taking NAD+ with Melatonin — may cause amplified fatigue, grogginess, or brain fog
Note: Antioxidants like Quercetin and Resveratrol can increase NAD+ levels five-fold, which may also magnify side effects such as hot flashes, nausea, skin itching/burning, calf cramps, headaches, abdominal pain, and fatigue.
SUBCUTANEOUS OR INTRAMUSCULAR ADMINISTRATION?
Intramuscular (IM)
- NAD is acidic, and may cause burning during injection, muscle soreness, and muscle stiffness
- High risk of histamine reactions (flushing, tightness in the chest, throat tingling, cough)
Subcutaneous (SubQ)
- Slower, steadier absorption; less painful than IM; better tolerated; smoother systemic rise
- Slower onset and less pronounced effects; may cause redness, firm nodules, and temporary swelling
NAD+: SYNERGISTIC STACKS
- Resveratrol – amplifies NAD+ production and supports mitochondrial function
- Quercetin – boosts NAD+ levels but may increase sensitivity to side effects
- NR (Nicotinamide Riboside) or NMN (Nicotinamide Mononucleotide) – precursors that help sustain NAD+ levels between injections
- Melatonin – supports circadian rhythm, but use with caution due to amplified fatigue when stacked with NAD+
- Glutathione – enhances cellular detox and works synergistically with NAD+ for anti-aging and metabolic health
- Pterostilbene – a more bioavailable alternative to resveratrol that enhances sirtuin activity in tandem with NAD+
Caution: Stacking NAD+ with other compounds that significantly raise NAD+ levels (like Quercetin or Resveratrol) may intensify side effects.
