5-Amino-1MQ is a small molecule compound designed to inhibit the enzyme NNMT (nicotinamide N-methyltransferase), which plays a key role in metabolic regulation and fat cell activity. By suppressing NNMT, 5-Amino-1MQ increases NAD⁺ levels and helps to accelerate energy metabolism, support healthy body composition, and reduce fat mass—especially visceral fat. It has gained attention for its potential to improve insulin sensitivity, mitochondrial function, and cellular repair, making it a popular option in fat loss, longevity, and athletic performance protocols.

KEY BENEFITS

• Promotes rapid fat loss without muscle breakdown
• Inhibits fat cell growth and reduces existing fat deposits
• NAD+ preservation: NAD+ is essential for mitochondrial function, which is central to the production of energy (ATP) within cells. As we age, NAD+ levels naturally decline, which can impair cellular energy production and lead to aging-related diseases. 5-Amino-1MQ’s ability to inhibit CD38 and preserve NAD+ levels is of significant interest for anti-aging and longevity research.
• Mitochondrial Biogenesis: 5-Amino-1MQ may also contribute to mitochondrial biogenesis, which refers to the generation of new mitochondria in cells. Mitochondria are responsible for energy production, and an increase in their numbers can improve overall cellular function and endurance.
• Improves insulin sensitivity and glucose tolerance
• Cognitive Health: By improving mitochondrial health and NAD+ levels, 5-Amino-1MQ may help protect brain cells from age-related neurodegenerative diseases like Alzheimer’s and Parkinson’s disease. NAD+ is essential for neuronal function and survival.
• Increased Brain Energy: The compound’s potential to enhance mitochondrial function could improve energy metabolism in the brain, supporting cognitive performance and possibly reducing brain fatigue
• Supports cellular longevity and anti-aging effects
• Improved Endurance: By enhancing mitochondrial activity and fat oxidation, 5-Amino-1MQ could improve physical endurance and exercise capacity. This may be particularly beneficial for endurance athletes or anyone looking to increase their stamina.
• May assist in reducing inflammation and oxidative stress
• Muscle Preservation: Because 5-Amino-1MQ promotes fat loss rather than muscle loss, it may help maintain lean muscle mass while reducing body fat. This makes it an attractive option for individuals undergoing body composition changes.

MECHANISM OF ACTION

5-Amino-1MQ works primarily by:

• NNMT Inhibition: Suppresses the enzyme responsible for downregulating energy metabolism in fat cells
• NAD⁺ Elevation: Increases intracellular NAD⁺, enhancing mitochondrial function and energy production
• Mitochondrial Optimization: Promotes thermogenesis and lipid oxidation via improved mitochondrial efficiency

The result is an upregulation of cellular metabolism, reduced fat accumulation, and improved lean body mass.

POSSIBLE SIDE EFFECTS

Common (usually temporary and mild):

• Headache
• Mild fatigue
• Digestive discomfort (bloating, nausea)
• Mild increase in heart rate

Rare:

• Skin irritation or redness at injection site
• Dizziness or jitteriness
• Temporary sleep disturbances

SIDE EFFECT MANAGEMENT

• Stay hydrated and eat balanced meals during the protocol
• Reduce dosage if fatigue or nausea occurs
• Use smaller split doses if needed to increase tolerance

CONTRAINDICATIONS

Do NOT use 5-Amino-1MQ if:

• You are pregnant or breastfeeding
• You have uncontrolled cardiovascular conditions
• You have liver or kidney impairment
• You are allergic to any excipients or BAC
• You are on medications that alter NAD metabolism without physician oversight

5-AMINO-1MQ: 10MG RECONSTITUTION AND DOSING PROTOCOLS

4-8 week cycles followed by a 2-4 week washout period

May be taken any time of day, although morning or afternoon is preferred

Does not need to be taken while fasting, although GI side effects may be mitigated by dosing along with a light meal

Subcutaneous Administration

4-Week Minimum Protocol

Mix with 2mL (200 units) of BAC water

• Weeks 1-2: Take 20 units (1mg), 1x/day
• Weeks 3-4: Take 40 units (2mg), 1x/day

Mix with 2mL (200 units) of BAC water

• Weeks 1-4: 20 units (1mg), 1x/day
• Weeks 5-8: 40 units (2mg), 1x/day OR continue with 20 units (1mg) for duration of cycle

Standard Protocol (Recommended)

Mix with 2mL (200 units) of BAC water

• Week 1: 20 units (1mg), 1x/day
• Week 2-3: 40 units (2mg), 1x/day
• Weeks 3-4: 60 units (3mg), 1x/day
• Weeks 5-6: 80 units (4mg), 1x/day
• Weeks 7-8: 100 units (5mg), 1x/day

5-AMINO-1MQ: 50MG RECONSTITUTION AND DOSING PROTOCOLS

4-6 week cycles followed by a 2-4 week washout period

May be taken any time of day, although morning or afternoon is preferred

Does not need to be taken while fasting; GI side effects may be mitigated by dosing along with a light meal

It is recommended to split the daily dose in to two or three injections to maintain a steady level of 5-Amino-1mq in the blood

Most effective when cycled at the start of a cutting period

Subcutaneous Administration

Recommended Protocol

Mix with 3mL (300 units) of BAC water

Days 1-3: 15 units (2.5mg) once per day, 7 days/week

Days 4-7 + weeks 2-6: 15 units (2.5mg) 2x/day, 7 days per week

Single Daily Dose Protocol

Mix with 3mL (300 units) of BAC water

Days 1-3: 15 units (2.5mg) once per day, 7 days/week

Days 4-7 + weeks 2-6: 30 units (5mg) once per day, 7 days/week

Stacking Suggestions

• AOD-9604 – Targets fat loss with no muscle deterioration
• CJC-1295 + Ipamorelin – Boosts growth hormone for enhanced metabolic effect
• GLP-1 Agonists (Semaglutide, Tirzepatide) – Supports appetite suppression and insulin regulation
• Glutathione or NAD+ Precursors – To amplify anti-aging and mitochondrial repair benefits

neuroprotective and cognitive-enhancing benefits. Its unique structure helps it cross the blood-brain barrier effectively, increasing its bioactive stability. 

ADDITIONAL ITEMS REQUIRED

• Bacteriostatic water
• Recommended insulin syringes for dosing: 1mL-30 gauge-8mm (5/16″) or .5mL-30 gauge-8mm (5/16″)

GENERAL DOSING GUIDELINES

8-12 week cycle followed by washout period equal to the length of the cycle you completed

Daily Dosing

Morning dosing recommended, although not absolutely mandatory; try to be consistent with your dosing time each day

You do not have to be fasted to dose

Subcutaneous Administration

RECONSTITUTION

DOSING PROTOCOL

Weeks 1-2: Take 9 units (300mcg) once per day

Weeks 3-4: Take 15 units (500mcg) once per day

Weeks 5-6: Take 23 units (750mcg) once per day

Weeks 7-8+: Take 30 units (1,000mcg) once per day

Adipotide (aka prohibitin-TP01 and fat-targeted proapoptotic peptide) designed to selectively eliminate blood vessels feeding white adipose (fat) tissue. It combines a homing sequence that targets fat-vasculature receptors (e.g. prohibitin/annexin A2) and a pro-apoptotic (cell death-inducing) sequence that triggers vessel cell death. The mechanism aims to starve fat cells of blood supply, leading to targeted fat tissue loss rather than systemic appetite suppression. Once the fat tissue has undergone apoptosis, it is cleared by the body. These results happen regardless of whether or not a person changes their diet or exercise regimens.

ADDITIONAL BENEFITS

• Targeted visceral fat reduction: Adipotide preferentially affected white adipose tissue, including visceral fat around organs. Visceral fat is linked to cardiovascular diseases, diabetes, and metabolic risk- reducing it can have outsized health benefits compared to losing general body weight.
• Improved insulin support, for Type 2 diabetics
• Because the targeting receptor, prohibitin, is also present in some tumor vasculature, it is of interest to cancer researchers
• Its non-CNS peripheral action provides a mechanistic contrast to central appetite-modulating drugs

POSSIBLE SIDE EFFECTS

INTERACTIONS

• Co-administration with other nephrotoxic agents (e.g. aminoglycosides, certain chemotherapeutics, high-dose contrast agents) could theoretically increase the risk of combined kidney toxicity.
• Because Adipotide influences fat tissue metabolism and possibly insulin sensitivity, theoretical interactions with glucose-lowering medications (e.g. insulin or hypoglycemic agents) or lipid-modifying agents could occur, although no controlled data exist.

CONTRAINDICATIONS

• Do not use if pregnant or breastfeeding
• Do not use if you have pre-existing renal impairment. Can be particularly hard on the kidneys.

ADIPOTIDE: 10MG – CYCLE AND DOSING CONSIDERATIONS

28-day cycle followed by 12-28 day washout period

Daily dosing for duration of the cycle 

May be dosed at any time, day or night

Adipotide does not have to be taken in a fasted state

Subcutaneous administration: abdominal region recommended

RECONSTITUTION

Mix with 2.5mL (250 units) of BAC water

DOSING PROTOCOL

Days 1-7: 8 units (.33mg), 1x/day

Days 9-14: 14 units (.55mg), 1x/day

Days 15-28: 25 units (1mg), 1x/day                

AOD-9604 is a fragment of the human growth hormone developed for the treatment of obesity. It is designed to mimic the fat-burning properties of hGH without its muscle-building effects or the common side effects.

This is achieved through Tyrosine (TYR), a portion of the amino acid sequence responsible for fat reduction and tissue repair. It mimics the effects of hGH on lipid metabolism without promoting growth or triggering pro-diabetic effects.

Where GLP-1 agonists suppress appetite and influence insulin secretion, AOD-9604 inhibits lipoprotein lipase activity in fat tissue, stimulating lipolysis in adipocytes. It specifically targets areas of the body with high fat deposits, preventing the conversion of carbohydrates into triglycerides and fatty acids and blocking the process of lipogenesis.

AOD-9604 can be particularly useful when stacked with GLP-1s to combat plateaus and target stubborn fat that diet and exercise alone may not eliminate.

BENEFITS

• Increases metabolism
• Stimulates lipolysis
• Inhibits lipogenesis (formation of fat cells)
• Promotes bone and cartilage repair
• Improves bone strength
• Does not impact blood sugar levels
• Enhances collagen production and skin elasticity
• Possesses anti-inflammatory properties (beneficial for arthritis)
• Enhances joint flexibility and mobility
• Prevents medication-related muscle-wasting

POSSIBLE SIDE EFFECTS

• Injection site reactions (redness, swelling, itching)
• Headache
• Fatigue
• Dizziness
• Cough
• Chest tightness or constriction
• Heart palpitations
• Cold-like symptoms

INTERACTIONS

Beta-adrenergic and fat-metabolism agents (e.g. clenbuterol, ephedrine, synephrine, stimulants): may produce palpitations and jitteriness

CONTRAINDICATIONS

• Do not use AOD-9604 if you are pregnant or breastfeeding
• Do not use AOD-9604 if you are pregnant or breastfeeding
• Do not take with an active malignancy
• Because it is metabolized via proteolytic degradation and renal clearance, do not take AOD-9604 if you have severe liver or kidney disease
• Discontinue use if you determine you are hypersensitive or allergIC

Do not use AOD-9604 if you are pregnant or breastfeeding.

RECONSTITUTION, DOSING, & OTHER CONSIDERATIONS

Dose 1-2 times per day, daily

First dose should be in the morning while fasted, and second should be while fasted (at least 1.5 hours following and preceding a meal)

If at all possible, remain fasted 3-4 hours following injection

Subcutaneous Administration

We advise purchasing Acetic Acid solution from one of the links included below in order to combat gelling if it occurs. AOD-9604 has a tendency to be a fairly unstable peptide ( high-maintenance in peptide form, if you will)

WHERE CAN I BUY ACETIC ACID?

Bireiao, 30mL, $11.99

https://a.co/d/0iJSh6dH

Quality Research Chemicals, 10mL, $11.95

https://a.co/d/07DdB6Ob

Zoniuu, 10mL, $9.99

https://a.co/d/03jnopya

STANDARD PROTOCOL (GENERAL BENEFITS/NON-FAT BURNING)

20 day cycle, followed by 10 day washout period; repeat for as long as necessary

Reconstitution

Mix with 2.5mL (250 units) of BAC water

Dosing

Take 15 units (300mcg) once per day

FAT BURNING/WEIGHT LOSS PROTOCOL

90 day cycle, followed by 30 day washout period

Reconstitution

Mix with 2.5mL (250 units) of BAC water

Dosing

Take 13 units (250mcg) twice per day: once immediately after waking and the second at least 1.5 hours after dinner

Stacking Suggestions

AOD-9604 stacks well with several peptides, especially for regenerative or fat-loss goals. Common combinations include:

• GLP-1s
• BPC-157
• TB-500
• Ipamorelin
• Sermorelin
• CJC No DAC

ARA-290 (aka Cibinetide) is a synthetic peptide derived from erythropoietin (EPO) designed to activate the innate repair receptor (IRR) and produce anti-inflammatory, neuroprotective, and tissue-repair effects without EPO’s red bood-cell-stimulating or pro-thrombotic actions.

Benefits

• Relief of neuropathic pain (especially small-fiber neuropathy)
• Strong anti-inflammatory
• Supports nerve repair/regeneration
• Restores immune balance in autoimmune disorders
• Tissue repair actions in injured, stressed, or ischemic tissues
• Provides adjunctive support for metabolic diseases like Type 2 diabetes, helping nerve complications, lipid/glucose improvements
• Does not produce clinically significant changes in electrolytes, liver, kidney, pancreas, erythrocytes, platelets, or leukocytes
• Improves lipid and glucose metabolism in diabetics

Interactions

• Concomitant use of strong immunosuppressants or biologic anti-inflammatory drugs may amplify immune modulation (caution advised)
• Agents that increase angiogenesis or that affect repair/vascular pathways may theoretically have additive or synergistic effects
• Given the repair/angiogenic axis, close monitoring of anticoagulent and antiplatelet medications is recommended
• Concomitant use of antidiabetic agents may require dose monitoring due to a risk of hypoglycemia

Contraindications

• Do not use if you are pregnant or breastfeeding
• Do not use if you determine that you are hypersensitive to this peptide
• Do not use if you have an active malignancy
• Do not use if you have uncontrolled cardiovascular disease or are at high risk of thrombosis

ARA-290: 16MG RECONSTITUTION AND DOSING

4, 8, or 12 week cycles followed by 2, 4, or 6 week washout periods

Subcutaneous Administration

Standard Protocol

Mix with 1.5mL (150 units) of BAC water

18, 28, or 38 units (2, 3, or 4mg), 1x/day, daily

Maximum Protocol

Mix with 1mL (150 units) of BAC water

75 units (8mg), 1x/day, daily, for a maximum of 4 weeks

BPC (Body Protection Compound) -157, a naturally occurring peptide found in human stomach juices (and in the gastric fluids of some other mammals) that works by stimulating agiogenesis (the formation of new blood vessels). It accelerates the wound-healing process through multiple mechanisms; is a potent anti-inflammatory; and has antioxidant benefits (protects from oxidative stress and damage). Well tolerated by most, this is one of the most popular peptides in the industry for its usefulness in treating a broad spectrum of injuries and ailments.

Benefits

• Enhances muscle recovery.
• Reduces inflammation, leading to a significant positive impact on the central nervous system (CNS), muscles, tendons, and damaged tissues.
• Increases muscle hypertrophy and strength.
• Supports tendon-to-bone healing.
• Stimulates collagen synthesis, resulting in anti-aging effects as the condition of the skin is improved, diminishes wrinkles, restores thickness to age-thinned skin, and improves elasticity.  Promotes hair growth.
• Leads to the formation of new blood vessels, which in turn improves vasculature, blood flow, and oxygenation of cardiovascular tissues.
• When injected in a region with scar tissue, it leads to a reduction in that scar tissue.
• Reduces fat mass.
• Protects against free radical damage to protect the brain and preserve brain function after exposure to harmful substances.
• Preserves and improves memory.
• Helps with mood regulation.
• Increases bone density.
• Reduces cartilage lesions and joint pain for improved leg mobility
• Interfers with the mechanisms that involved in ulcer formation; accelerates the rebuilding of stomach tissues.
• Elevates dopamine and serotonin levels in the brain, leading to analgesic (pain-relieving) effects.
• Accelerated healing of the colon in those with inflammatory bowel disease.
• Improves tendon, bone, and ligament healing by boosting levels of Epidermal Growth Factor (EGF), Fibroblast Growth Factor (FGF), and Vascular Endothelial Growth Factor (VEGF).
• Normalizes blood pressure: in those with low blood pressure, it exerts hypertensive effects by increasing blood pressure to within normal range; for those who have high blood pressure, it causes blood vessels to dilate, thus decreasing blood pressure.
• Prevents heart failure caused by potassium imbalance; protects against heart failure by restoring normal rhythm and electrial activities following potassium overdose; stabilizes heart rhythm of those suffering from potassium deficiency.
• Counteracts life-threatening conditions associated with hypercalcemia.
• Prevents severe side effects from many medications, including many medications for diabetes and psychiatric conditions. Combats catalepsy, somatosensory disturbance, and QT prolongation in the heart.
• Increases the production of growth factors that fight infections such as vascular endothelial growth factors, strengthening the immune system.
• Has antioxidant properties.
• Helps to reverse the adverse effects of acute and chronic alcohol intoxication.
• For Traumatic Brain Injury (TBI) sufferers, it reduces unconsciousness and lowers the prevalence of TBI-related deaths.
• For those with Multiple Sclerosis (MS), BPC administration decreases brain damage and other clinical abnormalities.
• Counteracts ischemic/reperfusion injuries (tissue damage caused when blood supply returns after a period of insufficient blood circulation in the brain), resulting in improved memory, orientation, and motor function.
• May possess anti-cancer activity by inducing programmed cell death (apoptosis) of cancer cells, and assembling and forming pores that disrupt the structures of cancer cells.

Conditions which may benefit from use of BPC-157

• Chronic inflammatory conditions.
• Arthritis/Osteoarthritis
• Eczema
• Ulcers
• Burn victims
• Achilles tendon injuries
• Muscle crush injuries
• Ligament injuries
• Nerve injuries
• Perforating corneal injuries or incisions
• Inflammatory bowel diseases (e.g. Crohn’s)

Plays a key roll in the Gut/Brain Axis

The gut-brain axis is the direct line of communication between the nervous system and the digestive system. Digestive health impacts neurological health and cognitive function to a substantial degree; it can protect the cells lining the gastrointestinal tract; impacts neurotransmitter balance; is being explored for potential treatments for anxiety and depression; reduces symptoms from ulcers, bowel disorders, Crohn’s disease, and other conditions where the gut-brain communication is disrupted; balances the microbial population in the gut.

While side effects are not common, you may experience:

• Nausea
• Diarrhea
• Appetite changes
• Gas/bloating
• Dizziness
• Headaches

Contraindications

• BPC-157 is toxic to fetuses and should not be used when pregnant or nursing.
• Do not take if you have chronic kidney disease. 
• Exercise caution if you have protein allergies, since BPC-157 is a protein.
• If you have an autoimmune disorder, it may be worsened by BPC-157, since it stimulates the immune system.
• Do not use BPC-157 with active cancer.
• In those with liver or kidney disease, BPC-157 may put additional strain on those organs.
• Exercise caution if you have a heart condition, as BPC-157 may cause a rise in blood pressure.

Subcutaneous or Intramuscular administration?

Subcutaneous:

Pro’s: Provides systemic benefits by entering the bloodstream and circulating throughout the body; good for both general healing and healing multiple injuries.

Con’s: Absorption is slower than in IM injections.

Intramuscular:

Pro’s: Faster absorption and more noticeable effects. Suitable for acute injuries, post-surgery recovery, or severe inflammation where quick effects are needed. Can be used for general benefits and systemic benefits and is also recommended for targeted pain relief, especially localized injections near the affected area. Con’s: Some may consider IM injections to be more difficult and/or more painful.

RECONSTITUTION AND DOSING

Administration: Subcutaneous or intramuscular injection
Typical Cycle Length: 8-10 weeks followed by 4-6 week washout
Frequency: 5 days per week, with 2 consecutive rest days (7 days per week okay for 8 week cycle)
Injury-Specific Use: Administer as close to injury site as appropriate OR into abdominal region (best systemic uptake)

BPC-157: 10MG VIAL

Mix with 2.5mL (250 units) of BAC water

• Week 1: 6 units (250mcg), 1-3 times per day
• Weeks 2–4:12 units (500mcg), 1-3 times per day
• Weeks 5–8: 18 units (750mcg), 1-3 times per day

BPC-157: 20MG VIAL

Mix with 2.5mL (250 units) of BAC water

• Week 1: 4 units (250mcg), 1-3 times per day
• Weeks 2–4: 6 units (500mcg), 1-3 times per day
• Weeks 5–8: 10 units (750mcg), 1-3 times per day

Stacking Suggestions

BPC-157 is often used as a core compound in regenerative peptide stacks. Common research pairings include:

• TB-500 – Synergistic healing of soft tissue, ligaments, and tendons
• Ipamorelin – For stimulating GH release and promoting full-body repair
• CJC No DAC – Enhances GH pulsatility alongside Ipamorelin
• Sermorelin – A GHRH analog to further support repair and recovery
• AOD-9604 – For combining fat reduction with accelerated healing
• GHK-Cu – Known for wound healing and skin repair
• Semax / Selank – Amplify neuroprotective effects and cognitive recovery

These stacks are commonly used in protocols for injury recovery, post-operative healing, or high-performance athletic regeneration.

Cagrilinitide (or “Cagri”) is a long-acting, lipidated, albumin-binding amylin agonist that targets both amylin and calcitonin receptors. It is used in the treatment of obesity, either on its own or in combination with GLP-1 receptor agonists. Amylin is co-secreted with insulin from pancreatic beta cells and regulates appetite, satiety, gastric emptying, and glucose control.

Combining Cagrilinitide with a GLP-1 like Semaglutide has a synergistic effect, amplifying weight loss beyond what either peptide achieves independently. Other benefits include improved circulation, reduced blood pressure, enhanced bone-building activity, and vasodilation.

OUTCOMES

• 6–10% body weight loss at 26 weeks (Cagrilinitide alone)
• 23–24.4% body weight loss at 68 weeks (combined with Semaglutide)
• Synergistic effect: up to 8% more weight loss vs. Semaglutide alone

POSSIBLE SIDE EFFECTS

• Injection site reaction (redness, swelling, itching, hives)
• Nausea
• Vomiting
• Constipation
• Fatigue
• Headache
• Diarrhea
• Heartburn
• Gallbladder stones (rare)

RECONSTITUTION, DOSING, AND MISC. CONSIDERATIONS

CAGRILINITIDE: 10MG

Mix with 2mL (200 units) of BAC water

8 week cycle followed by 4-8 week washout period

Subcutaneous Administration

• Week 1: 4 units (200mcg)
• Week 2: 8 units (400mcg)
• Wee 3: 15 units (750mcg)
• Week 4: 24 units (1.2mg)
• Week 5: 34 units (1.7mg)
• Week 6: 44 units (2.2mg)
• Week 7-8: 54 units (2.7mg)

Important Notes

• Always dose on the same day each week
• Ensure adequate hydration throughout the cycle
• Do not exceed 12 consecutive weeks of use
• Anti-Cagri antibodies may form with extended use (46–73% of users)

Stacking Suggestions

• Semaglutide, Tirzepatide, or Retatrutide – Boosts appetite suppression and fat loss via GLP-1 synergy- plateau breaker
• Tesofensine – Enhances energy expenditure and thermogenesis
• L-Carnitine – Supports fat metabolism and energy conversion
• AOD-9604 – Encourages lipolysis and body fat reduction without affecting blood sugar

CagriSema (Cagrilinitide + Semaglutide)

CagriSema is a powerful combination of Cagrilinitide, a long-acting amylin analogue, and Semaglutide, a GLP-1 receptor agonist. Together, they regulate satiety, control blood sugar, and significantly reduce body weight — achieving results comparable to Tirzepatide, but through a synergistic dual mechanism.

How It Works

• Cagrilinitide: A stabilized amylin analogue that resists enzymatic breakdown, prolonging its effects.
  • Induces satiety and reduces food intake
  • Suppresses glucagon (which raises blood sugar)
  • Slows gastric emptying, enhancing fullness
  • Promotes vasodilation, improving circulation
  • Supports bone health by reducing osteoclast activity and increasing osteoblast activity
• Semaglutide: A GLP-1 receptor agonist that:
  • Suppresses appetite via hypothalamic signaling
  • Reduces glucagon secretion
  • Delays gastric emptying
  • Aids glucose regulation

Research-Based Benefits

• Average 23–24.4% total body weight loss (vs. 15–17% with Semaglutide alone)
• Comparable to weight loss achieved by Tirzepatide
• Greater impact than using either compound individually
• May support bone density, cardiovascular health, and glucose control

Dosing Guidelines

CagriSema: 5MG/5MG
Mix with 1.5mL (150 units) of BAC water
Subcutaneous Administration — dose weekly, on the same day each week

 Even if transferring from Semaglutide or another GLP-1, start at the lowest dose due to the potent effects of Cagrilinitide.

Week-by-Week Titration Protocol

• Week 1–4: 5 units = 0.25mg
• Week 5–8: 10 units = 0.5mg
• Week 9–12: 15 units = 0.75mg
• Week 13–16: 20 units = 1mg
• Increase weekly as tolerated in 5-unit increments (0.25mg) until reaching:
  • 50 units = 2.5mg (maximum target dose)

Side Effects

Most are temporary and similar to other GLP-1 medications:

• Nausea
• Vomiting
• Constipation or diarrhea
• Headache
• Abdominal discomfort
• Injection site irritation

Contraindications

Do not use CagriSema if:

• You have a personal or family history of Medullary Thyroid Carcinoma (MTC) or MEN2
• You are allergic or hypersensitive to any of its components
• You have a history of pancreatitis
• You are pregnant or breastfeeding
• You are currently using another GLP-1 drug (including microdoses)

Use with caution if:

• You have renal dysfunction
• You have cardiovascular instability
• You have gastroparesis or other GI motility disorders

Storage

• Store refrigerated
• Do not freeze
• Shelf life: Up to 12 months when properly stored

Stacking Suggestions

• Tirzepatide (not to be used simultaneously) – An alternative to CagriSema with similar outcomes if CagriSema causes intolerance
• Glutathione – Supports liver detox, blood sugar balance, and reduces oxidative stress
• Vitamin B12 or MIC+C – Enhances energy, combats fatigue, and supports fat metabolism (especially important during calorie restriction)
• Tesofensine – May amplify appetite suppression and support dopamine-based reward pathway modulation
• GH Secretagogues (CJC-1295 + Ipamorelin) – Preserves muscle mass and supports metabolic health during fat loss
• Thymosin Alpha-1 – Supports immune balance in individuals with metabolic or inflammatory conditions

CJC-1295 No DAC

CJC-1295 No DAC (No Drug Affinity Complex) is a synthetic analog of growth hormone-releasing hormone (GHRH) designed to naturally stimulate the pituitary gland’s production of growth hormone (GH). It does this by mimicking GHRH activity and triggering powerful GH pulses—without remaining in circulation for extended periods like the DAC version. This shorter half-life closely mimics the body’s natural growth hormone rhythm, resulting in a more efficient and biologically aligned peptide therapy.

CJC No DAC has been shown to increase GH levels by up to 200–1000%, making it a powerful alternative to exogenous hGH, but without the drawbacks of suppression or long-term adaptation. It’s favored for fat loss, muscle recovery, anti-aging, and regenerative benefits.

Key Benefits

• Stimulates lean muscle growth and recovery
• Reduces adipose (fat) tissue
• Increases bone density and skeletal strength
• Promotes collagen synthesis (skin, joints, connective tissue)
• Improves sleep cycles and circadian rhythm
• Enhances energy levels and vitality
• Strengthens the immune system
• Accelerates connective tissue repair (tendons, ligaments)

Mechanism of Action

CJC-1295 No DAC acts on:

• Growth Hormone Pathways: Triggers GH pulses from the pituitary gland
• IGF-1 & LR3IGF-1: Elevates downstream markers responsible for muscle hypertrophy and regeneration
• Albumin Binding & Circulation: Designed for rapid absorption and release (30 min half-life), avoiding desensitization

This short-duration activity prevents receptor downregulation and mimics how GH is naturally secreted in healthy individuals, especially during deep sleep and fasting.

Regenerative & Systemic Benefits

• Boosts B and T-cell count in aging and immunocompromised individuals
• Increases antibody production, improving immune resilience
• Supports stem cell regeneration after organ or tissue damage
• Stimulates pancreatic cell proliferation
• May help repair cardiac tissue after heart attacks
• Enhances fertility and libido, especially in older adults
• Reduces triglycerides and supports cardiovascular health through improved body composition
• Shown to support cognition after neurological injury

CJC-1295 No DAC vs DAC Version

The primary difference between CJC No DAC and CJC DAC is the duration of action:

• CJC DAC: 6–8 day half-life, constant systemic exposure, may lead to desensitization over time
• CJC No DAC: 30-minute half-life, pulsed GH release, prevents adaptation, more closely mirrors natural GH production

CJC No DAC is preferred for longer-term use and bioidentical GH optimization.

Stacking with Ipamorelin

CJC-1295 No DAC is frequently stacked with Ipamorelin, a selective GH secretagogue that triggers additional GH pulses through a different pathway. When used together, the combo dramatically amplifies growth hormone output—leading to better muscle repair, fat loss, and recovery.

• Both are administered simultaneously, often twice or three times per day for optimal synergy
• This stack is safer and more effective than other GHRP combinations

Possible Side Effects

Common:

• Redness or irritation at injection site
• Temporary water retention
• Increased appetite
• Mild fatigue
• Flushing or warmth
• Light-headedness or dizziness
• Headache or nausea
• Digestive upset (bloating, diarrhea)
• Tingling sensations
• Mild hyperactivity or jitteriness

Rare:

• Temporary increase in blood pressure or pulse
• Hives or allergic skin reactions

Side Effect Management

• Start low, go slow: Gradually increase dosing over time
• Hydrate aggressively to manage water retention
• Use magnesium to counter water retention naturally
• For persistent side effects, consult a physician

Contraindications

Do NOT use CJC-1295 No DAC (alone or with Ipamorelin) if:

• You are pregnant or breastfeeding
• You are currently using other GH secretagogues or growth hormone supplements
• You have active cancer, untreated cardiovascular conditions, or hormonal disorders
• You are hypersensitive to peptide-based medications

Dosing Protocol

CJC-1295 NO DAC: 10MG – RECONSTITUTION AND DOSING

Mix with 2.5mL (250 units) of BAC (bacteriostatic) water

12-week cycle followed by 6-12 week washout period

Dose 5 consecutive days per week, followed by 2 rest-days

Most effective when fasted: Dose 2-3 hours after eating (absolutely no fats or carbs during that period of time, although black coffee and water are acceptable) OR 1.5 hours after eating a meal consisting solely of protein

Subcutaneous Administration

.3mL/cc (30-unit) or .5mL/cc (50-unit) syringes recommended

Low-Dose Protocol (General Benefits / Anti-Aging / Women)

• Weeks 1–4 (or 1–6): 3 units (100mcg), once daily
• Weeks 5–12: 5 units (150mcg), once daily

2x/Day Protocol (Muscle Tone, Mild Recovery)

• Week 1: 3 units (100 mcg), 2x/day
• Weeks 2–4 (or 2–6): 5 units (200 mcg), 2x/day
• Weeks 5–8 (or 7–12): 8 units (300 mcg), 2x/day

3x/Day Protocol (Athletes / Bodybuilders / Max Recovery)

• Days 1–3: 4 units (150 mcg), 3x/day
• Days 4–7: 5 units (200 mcg), 3x/day
• Weeks 2–3: 8 units (300 mcg), 3x/day
• Weeks 4–6: 10 units (400 mcg), 3x/day
• Weeks 7–12: 13 units (500 mcg), 3x/day

STACKING SUGGESTIONS

To maximize results and drive more conversions:

• Ipamorelin – Boosts GH secretion through synergistic action
• TB-500 / BPC-157 – For injury recovery, tissue regeneration, and joint health
• AOD-9604 – Supports fat metabolism without muscle loss
• GHK-Cu – Skin and tissue repair, anti-aging benefits
• Glutathione – Cellular detox, immune support