Kisspeptin is a neuropeptide produced by the hypothalamus, a part of the brain that controls the release of several important hormones in the body including gonadotropin-releasing hormone (GnRh), luteinizing hormone (LH), and follicle-stimulating hormone (FSH). Kisspeptin plays a major role in reproductive function in both men and women, secretion of aldosterone (which regulates water and salt balance), tumor suppression, and kidney function. Kisspeptin was originally named Metastin, a direct reflection of its ability to prevent the spread of cancer.
Benefits
- Increases testosterone levels by stimulating the release of LH, which in turn stimulates Leydig cells to produce testosterone
- Boosts immunity
- Regulates reproductive hormone release
- Enhances fertility
- Aids metabolic function and promotes weight loss
- Prevents wrinkles and signs of aging
- Boosts cognitive function
- Increases liver antioxidants
- Temporarily increases oxytocin
- Boosts insulin secretion
- Possible remedy for erectile dysfunction
- Treats fertility disorders
- Reacts with sexual stimuli and affects hormonal pulse frequency
- Lowers risk of heart disease
- Plays a role in puberty onset
- Potential treatment for polycystic ovarian syndrome
Kisspeptin and Non-Alcoholic Fatty Liver Disease
Kisspeptin helps reduce fat already deposited in the liver and prevents its initial accumulation, making it beneficial for managing early-stage NAFLD.
How It Works
- Binds to G-protein coupled receptors
- Stimulates GnRH → stimulates LH, FSH, and sex steroid secretion
- Increases testosterone, estrogen, progesterone
- Increases HCG-stimulated progesterone secretion in luteal cells
Alternative to HCG
Kisspeptin may serve as a natural alternative to HCG for maintaining fertility and hormonal balance in testosterone therapy. It stimulates LH and testosterone production, helping restore the HPG axis.
Possible Side Effects (Very uncommon)
- Diarrhea
- Sweating
- Headache
- Hot flushes
- Dizziness
- Shortened menstrual cycle
