Retatrutide is a powerful triple agonist peptide that targets GLP-1, GIP, and glucagon receptors—making it the most comprehensive metabolic peptide in its class.

Mechanism of Action

• GLP-1: Slows gastric emptying, reduces appetite, regulates insulin secretion
• GIP: Enhances insulin release, improves glucose tolerance
• Glucagon: Stimulates energy expenditure and promotes fat breakdown

Clinical Effectiveness

• Semaglutide: 17% average body weight loss after 68 weeks
• Tirzepatide: 24.7% body weight loss after 72 weeks
• Retatrutide: 17.5% in 24 weeks, 26.2% in 48 weeks

Additional Benefits

• Anti-inflammatory properties
• Collagen Support
• Wound Healing
• Angiogenesis
• Muscle Regeneration

Possible Side Effects

Common: Nausea, vomiting, headache, indigestion, constipation/diarrhea, abdominal discomfort

Rare: Gallbladder issues, pancreatitis, gastroparesis, kidney strain

Contraindications

Do NOT use if pregnant/nursing, have chronic kidney disease, advanced liver disease, severe GI disorders, family history of thyroid cancer, or are allergic to peptide-based medications.

Reconstitution and Dosing

Dose once every 7 days, same day each week. Remain at each dose for minimum 4 weeks. Subcutaneous Administration.

Retatrutide: 10MG — Mix with 1mL (100 units) of BAC water

• 2mg = 20 units, 4mg = 40 units, 6mg = 60 units, 8mg = 80 units, 10mg = 100 units

Retatrutide: 30MG — Mix with 2.5mL (250 units) of BAC water

• 2mg = 16 units, 4mg = 34 units, 6mg = 50 units, 8mg = 66 units, 10mg = 84 units, 12mg = 100 units

Retatrutide: 40MG — Mix with 2.5mL (250 units) of BAC water

• 2mg = 12 units, 4mg = 25 units, 6mg = 38 units, 8mg = 50 units, 10mg = 62 units, 12mg = 75 units

Stacking Suggestions

• AOD-9604 – Increases lipolysis and preserves muscle
• BPC-157 & TB-500 – Enhance healing
• GHK-Cu – For collagen production and skin tightening
• Semax / Selank – Mental clarity and mood support
• Glutathione – For detox support
• LIPO-C – To enhance energy and fat breakdown