5-Amino 1MQ
5-Amino-1MQ is a small molecule compound designed to inhibit the enzyme NNMT (nicotinamide N-methyltransferase), which plays a key role in metabolic regulation and fat cell activity. By suppressing NNMT, 5-Amino-1MQ increases NAD⁺ levels and helps to accelerate energy metabolism, support healthy body composition, and reduce fat mass—especially visceral fat. It has gained attention for its potential to improve insulin sensitivity, mitochondrial function, and cellular repair, making it a popular option in fat loss, longevity, and athletic performance protocols.
KEY BENEFITS
- Promotes rapid fat loss without muscle breakdown
- Inhibits fat cell growth and reduces existing fat deposits
- NAD+ preservation: NAD+ is essential for mitochondrial function, which is central to the production of energy (ATP) within cells. As we age, NAD+ levels naturally decline, which can impair cellular energy production and lead to aging-related diseases. 5-Amino-1MQ’s ability to inhibit CD38 and preserve NAD+ levels is of significant interest for anti-aging and longevity research.
- Mitochondrial Biogenesis: 5-Amino-1MQ may also contribute to mitochondrial biogenesis, which refers to the generation of new mitochondria in cells. Mitochondria are responsible for energy production, and an increase in their numbers can improve overall cellular function and endurance.
- Improves insulin sensitivity and glucose tolerance
- Cognitive Health: By improving mitochondrial health and NAD+ levels, 5-Amino-1MQ may help protect brain cells from age-related neurodegenerative diseases like Alzheimer’s and Parkinson’s disease. NAD+ is essential for neuronal function and survival.
- Increased Brain Energy: The compound’s potential to enhance mitochondrial function could improve energy metabolism in the brain, supporting cognitive performance and possibly reducing brain fatigue
- Supports cellular longevity and anti-aging effects
- Improved Endurance: By enhancing mitochondrial activity and fat oxidation, 5-Amino-1MQ could improve physical endurance and exercise capacity. This may be particularly beneficial for endurance athletes or anyone looking to increase their stamina.
- May assist in reducing inflammation and oxidative stress
- Muscle Preservation: Because 5-Amino-1MQ promotes fat loss rather than muscle loss, it may help maintain lean muscle mass while reducing body fat. This makes it an attractive option for individuals undergoing body composition changes.
MECHANISM OF ACTION
5-Amino-1MQ works primarily by:
- NNMT Inhibition: Suppresses the enzyme responsible for downregulating energy metabolism in fat cells
- NAD⁺ Elevation: Increases intracellular NAD⁺, enhancing mitochondrial function and energy production
- Mitochondrial Optimization: Promotes thermogenesis and lipid oxidation via improved mitochondrial efficiency
The result is an upregulation of cellular metabolism, reduced fat accumulation, and improved lean body mass.
POSSIBLE SIDE EFFECTS
Common (usually temporary and mild):
- Headache
- Mild fatigue
- Digestive discomfort (bloating, nausea)
- Mild increase in heart rate
Rare:
- Skin irritation or redness at injection site
- Dizziness or jitteriness
- Temporary sleep disturbances
SIDE EFFECT MANAGEMENT
- Stay hydrated and eat balanced meals during the protocol
- Reduce dosage if fatigue or nausea occurs
- Use smaller split doses if needed to increase tolerance
CONTRAINDICATIONS
Do NOT use 5-Amino-1MQ if:
- You are pregnant or breastfeeding
- You have uncontrolled cardiovascular conditions
- You have liver or kidney impairment
- You are allergic to any excipients or BAC
- You are on medications that alter NAD metabolism without physician oversight
5-AMINO-1MQ: 10MG RECONSTITUTION AND DOSING PROTOCOLS
4-8 week cycles followed by a 2-4 week washout period
May be taken any time of day, although morning or afternoon is preferred
Does not need to be taken while fasting, although GI side effects may be mitigated by dosing along with a light meal
Subcutaneous Administration
4-Week Minimum Protocol
Mix with 2mL (200 units) of BAC water
- Weeks 1-2: Take 20 units (1mg), 1x/day
- Weeks 3-4: Take 40 units (2mg), 1x/day
Mix with 2mL (200 units) of BAC water
- Weeks 1-4: 20 units (1mg), 1x/day
- Weeks 5-8: 40 units (2mg), 1x/day OR continue with 20 units (1mg) for duration of cycle
Standard Protocol (Recommended)
Mix with 2mL (200 units) of BAC water
- Week 1: 20 units (1mg), 1x/day
- Week 2-3: 40 units (2mg), 1x/day
- Weeks 3-4: 60 units (3mg), 1x/day
- Weeks 5-6: 80 units (4mg), 1x/day
- Weeks 7-8: 100 units (5mg), 1x/day
5-AMINO-1MQ: 50MG RECONSTITUTION AND DOSING PROTOCOLS
4-6 week cycles followed by a 2-4 week washout period
May be taken any time of day, although morning or afternoon is preferred
Does not need to be taken while fasting; GI side effects may be mitigated by dosing along with a light meal
It is recommended to split the daily dose in to two or three injections to maintain a steady level of 5-Amino-1mq in the blood
Most effective when cycled at the start of a cutting period
Subcutaneous Administration
Recommended Protocol
Mix with 3mL (300 units) of BAC water
Days 1-3: 15 units (2.5mg) once per day, 7 days/week
Days 4-7 + weeks 2-6: 15 units (2.5mg) 2x/day, 7 days per week
Single Daily Dose Protocol
Mix with 3mL (300 units) of BAC water
Days 1-3: 15 units (2.5mg) once per day, 7 days/week
Days 4-7 + weeks 2-6: 30 units (5mg) once per day, 7 days/week
Stacking Suggestions
- AOD-9604 – Targets fat loss with no muscle deterioration
- CJC-1295 + Ipamorelin – Boosts growth hormone for enhanced metabolic effect
- GLP-1 Agonists (Semaglutide, Tirzepatide) – Supports appetite suppression and insulin regulation
- Glutathione or NAD+ Precursors – To amplify anti-aging and mitochondrial repair benefits
FAQs From Same Category
neuroprotective and cognitive-enhancing benefits. Its unique structure helps it cross the blood-brain barrier effectively, increasing its bioactive stability.
ADDITIONAL ITEMS REQUIRED
- Bacteriostatic water
- Recommended insulin syringes for dosing: 1mL-30 gauge-8mm (5/16″) or .5mL-30 gauge-8mm (5/16″)
GENERAL DOSING GUIDELINES
8-12 week cycle followed by washout period equal to the length of the cycle you completed
Daily Dosing
Morning dosing recommended, although not absolutely mandatory; try to be consistent with your dosing time each day
You do not have to be fasted to dose
Subcutaneous Administration
RECONSTITUTION
Mix with 3mL (300 units) of bacteriostatic water
DOSING PROTOCOL
Weeks 1-2: Take 9 units (300mcg) once per day
Weeks 3-4: Take 15 units (500mcg) once per day
Weeks 5-6: Take 23 units (750mcg) once per day
Weeks 7-8+: Take 30 units (1,000mcg) once per day
Adipotide (aka prohibitin-TP01 and fat-targeted proapoptotic peptide) designed to selectively eliminate blood vessels feeding white adipose (fat) tissue. It combines a homing sequence that targets fat-vasculature receptors (e.g. prohibitin/annexin A2) and a pro-apoptotic (cell death-inducing) sequence that triggers vessel cell death. The mechanism aims to starve fat cells of blood supply, leading to targeted fat tissue loss rather than systemic appetite suppression. Once the fat tissue has undergone apoptosis, it is cleared by the body. These results happen regardless of whether or not a person changes their diet or exercise regimens.
ADDITIONAL BENEFITS
- Targeted visceral fat reduction: Adipotide preferentially affected white adipose tissue, including visceral fat around organs. Visceral fat is linked to cardiovascular diseases, diabetes, and metabolic risk- reducing it can have outsized health benefits compared to losing general body weight.
- Improved insulin support, for Type 2 diabetics
- Because the targeting receptor, prohibitin, is also present in some tumor vasculature, it is of interest to cancer researchers
- Its non-CNS peripheral action provides a mechanistic contrast to central appetite-modulating drugs
POSSIBLE SIDE EFFECTS
- Injection site reactions (redness, swelling, and/or itching)
- Loss of appetite
- Fatigue
- Dizziness
- Electrolyte imbalance
- Dehydration
- Dose-dependent, predictable, reversible renal injury and tubular dysfunction, including minimal to moderate tubular degeneration and necrosis after treatment, typically resolved after treatment.
- Increased urine output and slight dehydration have been observed, potentially reflecting early kidney function disruption
- Serum creatinine elevation indicate kidney strain, although typically mild and reversible
- Dehydration common, potentially linked to increased diuresis and kidney changes
INTERACTIONS
- Co-administration with other nephrotoxic agents (e.g. aminoglycosides, certain chemotherapeutics, high-dose contrast agents) could theoretically increase the risk of combined kidney toxicity.
- Because Adipotide influences fat tissue metabolism and possibly insulin sensitivity, theoretical interactions with glucose-lowering medications (e.g. insulin or hypoglycemic agents) or lipid-modifying agents could occur, although no controlled data exist.
CONTRAINDICATIONS
- Do not use if pregnant or breastfeeding
- Do not use if you have pre-existing renal impairment. Can be particularly hard on the kidneys.
ADIPOTIDE: 10MG – CYCLE AND DOSING CONSIDERATIONS
28-day cycle followed by 12-28 day washout period
Daily dosing for duration of the cycle
May be dosed at any time, day or night
Adipotide does not have to be taken in a fasted state
Subcutaneous administration: abdominal region recommended
RECONSTITUTION
Mix with 2.5mL (250 units) of BAC water
DOSING PROTOCOL
Days 1-7: 8 units (.33mg), 1x/day
Days 9-14: 14 units (.55mg), 1x/day
Days 15-28: 25 units (1mg), 1x/day
AOD-9604 is a fragment of the human growth hormone developed for the treatment of obesity. It is designed to mimic the fat-burning properties of hGH without its muscle-building effects or the common side effects.
This is achieved through Tyrosine (TYR), a portion of the amino acid sequence responsible for fat reduction and tissue repair. It mimics the effects of hGH on lipid metabolism without promoting growth or triggering pro-diabetic effects.
Where GLP-1 agonists suppress appetite and influence insulin secretion, AOD-9604 inhibits lipoprotein lipase activity in fat tissue, stimulating lipolysis in adipocytes. It specifically targets areas of the body with high fat deposits, preventing the conversion of carbohydrates into triglycerides and fatty acids and blocking the process of lipogenesis.
AOD-9604 can be particularly useful when stacked with GLP-1s to combat plateaus and target stubborn fat that diet and exercise alone may not eliminate.
BENEFITS
- Increases metabolism
- Stimulates lipolysis
- Inhibits lipogenesis (formation of fat cells)
- Promotes bone and cartilage repair
- Improves bone strength
- Does not impact blood sugar levels
- Enhances collagen production and skin elasticity
- Possesses anti-inflammatory properties (beneficial for arthritis)
- Enhances joint flexibility and mobility
- Prevents medication-related muscle-wasting
POSSIBLE SIDE EFFECTS
- Injection site reactions (redness, swelling, itching)
- Headache
- Fatigue
- Dizziness
- Cough
- Chest tightness or constriction
- Heart palpitations
- Cold-like symptoms
INTERACTIONS
Beta-adrenergic and fat-metabolism agents (e.g. clenbuterol, ephedrine, synephrine, stimulants): may produce palpitations and jitteriness
CONTRAINDICATIONS
- Do not use AOD-9604 if you are pregnant or breastfeeding
- Do not use AOD-9604 if you are pregnant or breastfeeding
- Do not take with an active malignancy
- Because it is metabolized via proteolytic degradation and renal clearance, do not take AOD-9604 if you have severe liver or kidney disease
- Discontinue use if you determine you are hypersensitive or allergIC
Do not use AOD-9604 if you are pregnant or breastfeeding.
RECONSTITUTION, DOSING, & OTHER CONSIDERATIONS
Dose 1-2 times per day, daily
First dose should be in the morning while fasted, and second should be while fasted (at least 1.5 hours following and preceding a meal)
If at all possible, remain fasted 3-4 hours following injection
Subcutaneous Administration
We advise purchasing Acetic Acid solution from one of the links included below in order to combat gelling if it occurs. AOD-9604 has a tendency to be a fairly unstable peptide ( high-maintenance in peptide form, if you will)
WHERE CAN I BUY ACETIC ACID?
Bireiao, 30mL, $11.99
Quality Research Chemicals, 10mL, $11.95
Zoniuu, 10mL, $9.99
STANDARD PROTOCOL (GENERAL BENEFITS/NON-FAT BURNING)
20 day cycle, followed by 10 day washout period; repeat for as long as necessary
Reconstitution
Mix with 2.5mL (250 units) of BAC water
Dosing
Take 15 units (300mcg) once per day
FAT BURNING/WEIGHT LOSS PROTOCOL
90 day cycle, followed by 30 day washout period
Reconstitution
Mix with 2.5mL (250 units) of BAC water
Dosing
Take 13 units (250mcg) twice per day: once immediately after waking and the second at least 1.5 hours after dinner
Stacking Suggestions
AOD-9604 stacks well with several peptides, especially for regenerative or fat-loss goals. Common combinations include:
- GLP-1s
- BPC-157
- TB-500
- Ipamorelin
- Sermorelin
- CJC No DAC
ARA-290 (aka Cibinetide) is a synthetic peptide derived from erythropoietin (EPO) designed to activate the innate repair receptor (IRR) and produce anti-inflammatory, neuroprotective, and tissue-repair effects without EPO’s red bood-cell-stimulating or pro-thrombotic actions.
Benefits
- Relief of neuropathic pain (especially small-fiber neuropathy)
- Strong anti-inflammatory
- Supports nerve repair/regeneration
- Restores immune balance in autoimmune disorders
- Tissue repair actions in injured, stressed, or ischemic tissues
- Provides adjunctive support for metabolic diseases like Type 2 diabetes, helping nerve complications, lipid/glucose improvements
- Does not produce clinically significant changes in electrolytes, liver, kidney, pancreas, erythrocytes, platelets, or leukocytes
- Improves lipid and glucose metabolism in diabetics
Interactions
- Concomitant use of strong immunosuppressants or biologic anti-inflammatory drugs may amplify immune modulation (caution advised)
- Agents that increase angiogenesis or that affect repair/vascular pathways may theoretically have additive or synergistic effects
- Given the repair/angiogenic axis, close monitoring of anticoagulent and antiplatelet medications is recommended
- Concomitant use of antidiabetic agents may require dose monitoring due to a risk of hypoglycemia
Contraindications
- Do not use if you are pregnant or breastfeeding
- Do not use if you determine that you are hypersensitive to this peptide
- Do not use if you have an active malignancy
- Do not use if you have uncontrolled cardiovascular disease or are at high risk of thrombosis
ARA-290: 16MG RECONSTITUTION AND DOSING
4, 8, or 12 week cycles followed by 2, 4, or 6 week washout periods
Subcutaneous Administration
Standard Protocol
Mix with 1.5mL (150 units) of BAC water
18, 28, or 38 units (2, 3, or 4mg), 1x/day, daily
Maximum Protocol
Mix with 1mL (150 units) of BAC water
75 units (8mg), 1x/day, daily, for a maximum of 4 weeks