Vasoactive Intestinal Peptide (VIP) is a 28-amino-acid endogenous neuropeptide hormone found throughout the central nervous system, peripheral nerves, immune system, lungs, and gastrointestinal tract. It is a potent regulatory peptide widely distributed in the brain, lungs, immune cells, gut, cardiovascular system. It exerts its effects through cAMP signaling, vasodilation, immune modulation, neuroprotection, and anti-inflammatory cytokine balance. Key cellular actions include suppression of TNF-a, IL-6m IL-12, increases IL-10 (anti-inflammatory cytokine), regulates Th1/Th2/Th17 balance, and protects endothelial and epithelial barriers.
BENEFITS
Immune Modulation and Autoimmune Regulation (VIP is one of the strongest endogenous anti-inflammatory peptides)
- Suppresses autoimmune-driven inflammation
- Downregulates overactive macrophages and T-cells
- Promotes immune tolerance
- VIP does not broadly suppress immunity like steroids
Pulmonary and Respiratory Benefits (VIP is highly expressed in the lungs)
- Potent bronchodilator
- Reduces pulmonary inflammation
- Improves oxygen diffusion
- Protects alveolar epithelial cells
Neurological and Cognitive Effects (acts as a neurotrophic and neuroprotective peptide)
- Enhances cerebral blood flow
- Protects neurons from oxidative stress
- Supports myelin integrity
- Improves circadian rhythm regulation
Gastrointestinal and Motility Support (is essential for gut homeostasis)
- Relaxes smooth muscle
- Increases intestinal blood flow
- Enhances mucosal barrier integrity
- Reduces gut inflammation
Vascular and Cardiovascular Effects
- Strong vasodilator
- Improves endothelial function
- Reduces platelet aggregation
- Enhances microcirculation
Hormonal and Endocrine Effects (interacts with hypothalamic-pituitary signaling)
- Modulates ACTH and cortisol rhythms
- Influences prolactin release
- Support circadian hormone balance
- These effects are part of why VIP is often used in complex chronic illness protocols in late-stage disease
Off-Label Use (when used internasally and after inflammatory markers normalize, MARCoNS addressed, and mold/toxin exposure eliminated, VIP may be used for the following)
- Improved cognition
- Reduced fatigue
- Better exercise tolerance
- Improved oxygenation
- Restoration of quality of life
ADDITIONAL BENEFITS
- Immune modulation: VIP helps balance immune responses, making it helpful for autoimmune conditions, chronic inflammation, and immune deficiencies
- Respiratory health: VIP can significantly improve lung function and reduce inflammation, which benefits those with asthma or mold-related illnesses
- Brain function and cognition: by promoting blood flow and reducing neuroinflammation, VIP supports cognitive function and may help with brain fog and fatigue
- Gut health: helps regulate gut motility and reduce intestinal inflammation
- Cardiovascular support: it improves circulation by dilating blood vessel
VIP HAS THERAPEUTIC VALUE IN TREATING THE FOLLOWING:
- Rheumatoid arthritis
- Multiple sclerosis
- Inflammatory bowel disease
- IBS (especially constipation-predominant)
- Sarcoidosis
- Traumatic Brain Injury (TBI)
- Autoimmune lung disease
- Chronic inflammation
- Mold toxicity
- Respiratory disorders
- Oxygen delivery
- Mucosal repair
- Alvelar ptrotectom
- Asthma
- Gut ischemia
- Post-infectious dysmotility
- Cognitivie fatigue
- Long COVID
- Osteoarthritis
- Oxidative stress
- Tissue repair
- Brain fog
- Seasonal allergies
- COPD
- Pulmonary hypertension
- Microvascular dysfunction
- Raynaud-like conditions
- ARDS
- Chronic fatigue
- Viral infections
- Cardiovascular health
- Digestive discomfort
- Neuroinflammation
- Circadian rhythm regulation
- Autoimmune disease
- Hormonal imbalances
- Free radical damage
- Immune deficiencies
POSSIBLE SIDE EFFECTS
- Flushing
- Headache
- Lightheadedness /dizziness
- Nausea
- Fatigue (during initial adaptive period)
- Hypotension
- Transient anxiety
- Increased urination
CONTRAINDICATIONS
- Active infection
- Uncontrolled autoimmune flare
- Cancer with angiogenesis risk
- Severe hypotension
- Pregnant or breastfeeding
