PE-22-28 is a potent PACAP analog used in research on neuroprotection, cellular signaling, and oxidative stress. It also supports studies on metabolic modulation, protein synthesis, tissue repair, and muscle growth for recovery, aging, and performance enhancement.
Molecular Formula: C₁₆H₂₆N₄O₈
Molecular Weight:39 g/mol
Purity: ≥99%
For research purposes only. This product is supplied exclusively for scientific laboratory research and analytical purposes. It is not intended for human or animal use, and must not be misused in any way that contravenes MHRA regulations or applicable laws.
PE-22-28 is a 7-amino acid peptide derived from spadin that acts as a potent TREK-1 channel inhibitor, primarily researched for rapid antidepressant effects, enhanced neurogenesis, and improved cognitive function. It promotes neuronal repair (synaptogenesis), reduces anxiety, and offers neuroprotective properties with fewer side effects than traditional antidepressants.
Key Benefits of PE-22-28 Peptide:
Rapid Antidepressant & Mood Regulation: Studies suggest PE-22-28 acts quickly to alleviate depressive symptoms by inhibiting the TREK-1 channel in the hippocampus.
Neurogenesis & Synaptogenesis: Promotes the birth of new neurons (neurogenesis) and enhances synaptic connections (synaptogenesis), which can help reverse hippocampal atrophy
Neuroprotection: Provides protective effects against neurodegenerative diseases like Alzheimer’s and Parkinson’s.
Reduced Anxiety: Research in animal models has demonstrated a decrease in anxiety-like behaviors.
Potential Physical Benefits: In addition to cognitive benefits, it has been associated with increased muscle function and potential wound healing improvements.
Usage and Research:
PE-22-28 is typically used in short-term, cyclical "bursts" to tune the nervous system rather than for chronic daily use. It is often studied in preclinical models as a faster-acting alternative to traditional SSRIs.
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