SL-UP-332 is a synthetic research compound known as an "exercise mimetic" that shows promise in animal studies for treating metabolic diseases, enhancing endurance, and potentially aiding in the prevention of severe COVID-19. It works by activating estrogen-related receptors (ERRs), which are proteins that regulate cellular energy metabolism.
SL-UP-332 is a synthetic research compound known as an "exercise mimetic" that shows promise in animal studies for treating metabolic diseases, enhancing endurance, and potentially aiding in the prevention of severe COVID-19. It works by activating estrogen-related receptors (ERRs), which are proteins that regulate cellular energy metabolism.
Key Potential Benefits
Based on current research, primarily in mice models, the potential benefits of SLU-PP-332 include:
Weight Loss and Fat Metabolism: It increases energy expenditure and fatty acid oxidation, leading to decreased fat mass accumulation without affecting appetite or food intake in obese mice.
Improved Exercise Endurance: It promotes the development of fatigue-resistant (oxidative) muscle fibers and can enhance physical stamina and running endurance in mice.
Metabolic Health Management: It may help manage conditions like obesity, type 2 diabetes, heart failure, and nonalcoholic fatty liver disease (NAFLD) by improving glucose tolerance and insulin sensitivity.
Mitochondrial Function Enhancement: It boosts mitochondrial biogenesis and function, which are crucial for cellular energy production.
Anti-Inflammatory Effects: Early data suggests it may modulate inflammatory pathways and reduce the production of pro-inflammatory cytokines (such as IL-6 and TNF-α).
Potential COVID-19 Prevention/Treatment: It has been hypothesized to improve mitochondrial functions, inhibit inflammatory cytokines, and reduce entry points for the SARS-CoV-2 virus in adipose tissue, potentially preventing severe forms of COVID-19 and treating Long COVID symptoms.
