FOX04 (10mg) is a high-purity peptide for advanced senescence research, enabling studies on targeting and eliminating aged or dysfunctional cells. It supports investigations into senolysis and aging biology, providing reliable insights for experimental aging and longevity studies.
For research purposes only. This product is supplied exclusively for scientific laboratory research and analytical purposes. It is not intended for human or animal use, and must not be misused in any way that contravenes MHRA regulations or applicable laws.
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FOXO4-DRI (FOXO4-D-Retro-Inverso) is a senolytic peptide designed to selectively eliminate senescent ("zombie") cells by disrupting the FOXO4-p53 interaction, triggering apoptosis in these cells. Studies in mice indicate it reverses key aging markers, including increased fur density, improved kidney and liver function, and enhanced physical fitness.
Key Benefits of FOXO4-DRI
Based on preclinical studies, potential benefits include:
Selective Elimination of Senescent Cells: It specifically targets and kills senescent cells while leaving healthy cells unharmed.
Anti-Aging and Physical Function: In, mice, it improved fur density, increased fitness, and restored strength.
Organ Function Restoration: It has been shown to counteract the loss of liver and kidney function associated with aging.
Reduced Frailty: The peptide helps mitigate age-related frailty.
Improved Vascular Health: It reduces endothelial cell senescence, helping to maintain, and in some cases improve, vascular function.
Alleviation of Age-Related Conditions: Research indicates it can help with age-related testosterone deficiency by targeting Leydig cells and has potential applications in reducing pulmonary fibrosis.
Reduced Chemotherapy Toxicity: It has demonstrated the ability to counteract senescence induced by chemotherapy.
Important Considerations
Preclinical Status: The majority of research on FOXO4-DRI has been conducted on mouse models.
No Increased Lifespan in Mice: While it improved healthspan (the quality of life) in mice, it did not significantly increase their total lifespan.
Mechanism of Action: It acts by blocking the interaction between FOXO4 and p53, which causes senescent cells to undergo apoptosis.
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